Detalhe da pesquisa
1.
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Cell
; 172(1-2): 373-386.e10, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29224780
2.
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.
Mol Cell
; 81(22): 4692-4708.e9, 2021 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34555355
3.
PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair.
EMBO J
; 43(6): 1015-1042, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38360994
4.
Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.
Nature
; 608(7923): 609-617, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35948633
5.
Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.
Nature
; 609(7929): E13, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-36050473
6.
Replication fork stability confers chemoresistance in BRCA-deficient cells.
Nature
; 535(7612): 382-7, 2016 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27443740
7.
BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance.
Nat Methods
; 15(2): 134-140, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29256493
8.
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Nature
; 521(7553): 541-544, 2015 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25799992
9.
TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming.
Stem Cells
; 35(1): 147-157, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27350605
10.
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.
Proc Natl Acad Sci U S A
; 112(27): 8409-14, 2015 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26100884
11.
Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells.
Nature
; 539(7629): 456, 2016 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27680696
12.
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.
Sci Adv
; 9(20): eadg2235, 2023 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37196082
13.
Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors.
Cell Rep
; 42(5): 112538, 2023 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37209095
14.
Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas.
Cell Rep
; 23(1): 100-111, 2018 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29617652
15.
The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.
Cell Rep
; 23(7): 2107-2118, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29768208
16.
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Cancer Cell
; 33(6): 1078-1093.e12, 2018 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29894693
17.
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Nat Cell Biol
; 19(11): 1371-1378, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29035360
18.
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.
Nat Commun
; 8: 15981, 2017 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28714471
19.
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Cancer Cell
; 35(6): 950-952, 2019 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31185216